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・ Small nucleolar RNA SNORD98
・ Small nucleolar RNA SNORD99
・ Small nucleolar RNA snoZ7/snoR77
・ Small nucleolar RNA snR48
・ Small nucleolar RNA snR53
・ Small nucleolar RNA snR54
・ Small nucleolar RNA snR55/Z10
・ Small nucleolar RNA snR57
・ Small nucleolar RNA snR60/Z15/Z230/Z193/J17
・ Small nucleolar RNA snR61/Z1/Z11
・ Small nucleolar RNA snR64
・ Small nucleolar RNA snR66
・ Small nucleolar RNA snR69
・ Small nucleolar RNA snR71
・ Small nucleolar RNA sR-tMet
Small nucleolar RNA sR8
・ Small nucleolar RNA TBR17
・ Small nucleolar RNA TBR5
・ Small nucleolar RNA TBR7
・ Small nucleolar RNA U2-19
・ Small nucleolar RNA U2-30
・ Small nucleolar RNA U3
・ Small nucleolar RNA U6-53/MBII-28
・ Small nucleolar RNA U83B
・ Small nucleolar RNA Z101
・ Small nucleolar RNA Z102/R77
・ Small nucleolar RNA Z103
・ Small nucleolar RNA Z105
・ Small nucleolar RNA Z107/R87
・ Small nucleolar RNA Z112


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Small nucleolar RNA sR8 : ウィキペディア英語版
Small nucleolar RNA sR8

Small nucleolar RNA sR8 is a non-coding RNA belonging to the C/D box class of snoRNAs. sR8, along with other C/D box snoRNAs, performs 2′-''O''-methylation of ribose on a target strand of ribosomal RNA. Targeting is achieved through the C and D box components, which are short sections of conserved sequences, as well as C'/D' boxes (internal equivalents of the C and D boxes). These sequences base-pair with nucleotides in the target rRNA to direct their methylation.
sR8 RNA operates alongside protein components in a ribonucleoprotein (RNP) complex. sR8 is able to guide the methylation of targets found within structured stem-loops, which implies that a component of the complex is able to unwind such structures.〔
==As a model system==
sR8 is considered a 'model'〔 C/D box sRNA and has been used in several experiments investigating the nature of C/D box snoRNAs and ribonucleoprotein complexes. It is particularly useful in studies because the RNP can be entirely constructed ''in vitro''.〔
sR8 RNA from the hyperthermophile ''Methanocaldococcus jannaschii'' has been used to elucide the 3-dimensional structure of a C/D box RNP. The structure was unexpectedly found to be dimeric, wherein two RNA molecules bind with several proteins in the same complex.〔

抄文引用元・出典: フリー百科事典『 ウィキペディア(Wikipedia)
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